Association of low levels of first trimester Pregnancy Associated Plasma Protein (PAPP-A) with adverse pregnancy outcomes: An observational study
نویسندگان
چکیده
منابع مشابه
Pregnancy-associated plasma protein-E (PAPP-E).
A full-length cDNA encoding a novel human protein was cloned from placenta cDNA. The corresponding 1542 amino acid protein sequence was termed 'pregnancy-associated plasma protein-E' (PAPP-E) as it shows a 62% homology to the human pregnancy-associated plasma protein-A (PAPP-A) that is a diagnostic marker for trisomies, especially Down syndrome. The conserved domain structure contains five moti...
متن کاملThe risk of adverse pregnancy outcome in the setting of very low first trimester maternal PAPP-A levels
Methods A retrospective analysis of 961 pregnancies with PAPP-A < 0. 3 MoM and 961 age-matched controls with PAPP-A level 0. 9-1. 1 MoM. The study period was a four years (2009-2012). The FTS was performed according to the guidelines of Finnish Ministry of Social Affairs and Health. The gestational age was estimated by the fetal crown-rump length and the NT measurement was performed according t...
متن کاملAssociation and predictive accuracy of high TSH serum levels in first trimester and adverse pregnancy outcomes.
CONTEXT High serum levels of TSH have been associated with adverse pregnancy outcomes by some studies, and not by others. OBJECTIVE The aim of the study was to assess the association between high levels of TSH in the first trimester of pregnancy and adverse pregnancy outcomes; and to examine the predictive accuracy as a screening test. SETTING AND PARTICIPANTS Serum levels of TSH were measu...
متن کاملPrevalence and association of adverse pregnancy outcomes in pregnant women with abnormal levels of serum markers in the first trimester of pregnancy at Tehran Nasl-Omid Center in 2012-2016
Background: Due to the role of the markers of the first trimester of pregnancy in the adverse pregnancy outcomes and the inadequacy of studies conducted in Iran, in this study the frequency and relationship between adverse pregnancy outcomes in mothers with abnormal PAPP-A and free βHCG values were investigated. Materials and methods: In this cross- sectional study, 501 pregnant women referred ...
متن کاملCorrelation between first trimester fetal bone length and maternal serum pregnancy-associated plasma protein-A (PAPP-A).
BACKGROUND Pregnancy-associated plasma protein-A (PAPP-A) is produced by the embryo and placenta during pregnancy, and its maternal serum concentrations are related to subsequent fetal growth. Evidence from animal models and in vitro experiments suggests that PAPP-A is particularly involved in the regulation of bone development. The aim of this study was to assess the correlation between late f...
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ژورنال
عنوان ژورنال: Obstetrics and Gynecology Reports
سال: 2017
ISSN: 2515-2955
DOI: 10.15761/ogr.1000116